Subchronic Toxicity of Triethylenetetramine Dihydrochloride in B6C3F1 Mice and F344 Rats
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Subchronic toxicity of triethylenetetramine dihydrochloride in B6C3F1 mice and F344 rats.
Triethylenetetramine dihydrochloride (trien-2HCl; CAS No. 38260-01-04), a chelating agent used to treat Wilson's disease patients who are intolerant of the drug of choice, was tested for subchronic toxicity in B6C3F1 mice and F344 rats. Mice and rats received trien-2HCl in the drinking water at concentrations of 0, 120, 600, or 3000 ppm for up to 92 days. Twenty mice and 18 rats of each sex wer...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1996
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/29.2.185